Effectiveness of specific antibiotic/steroid combinations for therapy of experimentalPseudomonas aeruginosakeratitis

摘要: Ciprofloxacin and prednisolone, but not an aminoglycoside dexamethasone, were previously found to be effective in killing bacteria reducing inflammation for the treatment of Pseudomonas keratitis. We investigated therapeutic effectiveness tobramycin/prednisolone ciprofloxacin/dexamethasone a rabbit model experimental keratitis increase our understanding antibiotic/steroid combinations. To knowledge, this is first analysis combination ciprofloxacin dexamethasone Two experiments conducted. In experiment, 36 rabbits divided into six groups: 1) untreated; 2) prednisolone acetate, 1.0%; 3) phosphate, 4) tobramycin, 1.36%; 5) tobramycin plus acetate; 6) phosphate. second 23 four ciprofloxacin, 0.3%, alcohol, 0.1%; ciprofloxacin; alcohol. Topical antibiotic and/or steroid was given 10 h, from 16 26 h postinfection, one drop every 15 min hour then 30 remaining 9 h. At 27 eyes evaluated by slit lamp examination (SLE) assayed presence terms colony forming units (CFU) per cornea. Both acetate phosphate reduced ocular (as determined SLE), compared with no (P < or = 0.036); more 0.005). Tobramycin alone also significantly SLE, 0.006). The bactericidal activity affected either formulation.(ABSTRACT TRUNCATED AT 250 WORDS)