Targeting the mammalian target of rapamycin pathway with everolimus: Implications for the management of metastatic breast cancer:
作者： Vin Cci Ng , Jeremy J Johnson , Sandra Cuellar
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摘要: The inhibitors of mammalian target rapamycin (mTOR) have documented antitumor activity via disruption various signaling pathways leading to impaired cellular growth, proliferation, and survival. In preclinical studies, mTOR use in combination with hormonal therapy has shown promising results overcoming endocrine resistance breast cancer cells. role everolimus was established the Breast Cancer Trial Oral Everolimus-2 (BOLERO-2) trial exemestane for patients advanced metastatic hormone receptor-positive (HR+) cancer, who relapsed after initial manipulation. study met its primary endpoint significant improvement progression free survival (PFS) a median time 6.9 months group versus 2.8 group. Favorable improvements PFS were reported across all patient subgroups regardless age, Eastern Cooperative Oncology Group performance status, number o...
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