The Impact of Antimalarial Resistance on the Genetic Structure of Plasmodium falciparum in the DRC
作者： Robert Verity , Ozkan Aydemir , Nicholas F. Brazeau , Oliver J. Watson , Nicholas J. Hathaway
DOI: 10.1101/656561
关键词:
摘要: ABSTRACT The Democratic Republic of the Congo (DRC) harbors 11% global malaria cases, yet little is known about spatial and genetic structure parasite population in that country. We sequenced 2537 Plasmodium falciparum infections, including a nationally representative sample from DRC samples surrounding countries, using molecular inversion probes - novel high-throughput genotyping tool. identified an east-west divide haplotypes to confer resistance chloroquine sulfadoxine-pyrimethamine. Furthermore, we highly related parasites over large geographic distances, indicative gene flow migration. Our results were consistent with background isolation by distance combined effects selection for antimalarial drug resistance. This study provides high-resolution view across country Africa baseline how implementation programs may impact populations.
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