Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.

摘要: Prognostic variables in breast cancer are urgently needed to individualize adjuvant cytotoxic therapy, especially those patients where metastases the lymph nodes have not been detected (node-negative disease). So far histomorphological criteria, determination of receptors for steroid hormones or EGF (epidermal growth factor), protease cathepsin D DNA-ploidy used distinguish between low- and high-risk patients. High-risk a higher incidence recurrences and/or shorter overall survival after surgery primary tumour than low-risk (node-positive; hormone-receptor-negative) would receive hormone therapy chemotherapy. In node-negative patient, is only recommended if high content aneuploidy (or S-phase diploid tumours) has diagnosed. Determination extracts as variable based on fact that invasion metastasis correlated with elevated levels tumour-associated proteases such cathepsins B D, collagenase IV plasminogen activators. The urokinase-type activator (uPA) which secreted by cells an enzymatically inactive proenzyme (pro-uPA) seems play key role mediating cell tissues. Receptor-bound uPA converts into serine plasmin then degrades extracellular matrix surrounding (tumour stroma). We localized pro-uPA/uPA immunohistochemically paraffin-embedded formalin-fixed tissue sections. Pro-uPA/uPA was cytoplasm plasma membrane reflecting receptor-bound pro-uPA/uPA.(ABSTRACT TRUNCATED AT 250 WORDS)