Properties of alkyl hydroxycinnamates and effects on Pseudomonas fluorescens.

摘要: Alkyl esters of six hydroxycinnamic acids, shown to be active antimicrobial agents when tested against Pseudomonas fluorescens, were further investigated for their effects this organism. There was no statistically significant adaptation by organism either the methyl caffeic, rho-coumaric, cinnamic, or rho-hydroxybenzoic acids. Mixtures these compounds taken two at a time gave least additive effects, with some mixtures showing synergism. Preliminary work also performed determine mode inhibitory action compounds. The inhibition oxygen utilization correlated well growth inhibition. Short-term lethality studies showed that none alkyl propyl paraben produced any bacteriocidal effects. Oil-water partition coefficients determined and have correlation inhibitions. These all point specific action, based in part on cellular energy depletion, rather than nonspecific membrane-disrupting other phenolic agents.