Molecular pathogenesis of chronic kidney disease

摘要: High blood pressure, poor glycemic control, obesity, metabolic syndrome, dyslipidemia, smoking and older age are the risk factors for susceptibility to initiation of CKD. In these conditions, systemic pressure can be transmitted glomerular capillary network because impairment autoregulationary mechanism existing on afferent arteriole glomerulus. Glomerular hypertension endothelial dysfunction regarded as common mechanisms underlying in development Albuminuria reflects dysregulation hemodynamics vascular damage. Low-grade albuminuria (below current microalbuminuria threshold) is independent factor CVD. The renin-angiotensin system(RAS), insulin resistance increased sympathetic nerve activity implicated dysfunction. Endothelial could caused by decrease BH4 resultant eNOS uncoupling. which link CKD cardiovascular diseases.