Cellular and molecular mechanisms of chikungunya pathogenesis.

摘要: Chikungunya virus (CHIKV) is an arthropod-borne that causes chikungunya fever, a disease characterized by the onset of fever and rashes, with arthralgia as its hallmark symptom. CHIKV has re-emerged over past decade, causing numerous outbreaks around world. Since late 2013, reached shores Americas, more than million cases infection. Despite concentrated efforts to understand pathogenesis disease, further remain threat. This review highlights important findings regarding CHIKV-associated immunopathogenesis offers insights into future directions. article forms part symposium in Antiviral Research on "Chikungunya discovers New World."