Short- and long-term effects of estrogen and synthetic anabolic hormone in postmenopausal osteoporosis

摘要: In 29 women with postmenopausal osteoporosis, the proportion of total bone surface undergoing resorption or formation was evaluated by microradiography iliac crest biopsy samples before and after short-term (2(1/2)-4 months) long-term (26-42 months for estrogen 9-15 anabolic hormone) treatment. After administration, values bone-resorbing surfaces decreased, although less prominently than therapy. The magnitude this decrease positively correlated pretreatment value (P < 0.001). When used as a covariable, hormone appeared to be equally effective. For bone-forming surfaces, therapy either had no effect but significantly decreased values. Serum immunoreactive parathyroid (IPTH) increased therapy; change in IPTH inversely related serum calcium 0.001, sign test). We conclude that primary sex hormones osteoporosis is level resorption, perhaps decreasing responsiveness endogenous hormone. However, favorable effect, at least part, negated treatment secondary formation. Our data are consistent concept maximal benefit can derived from arrest slowing progession loss.