Delivery systems for enhancing oncolytic adenoviruses efficacy

摘要: Oncolytic adenovirus (OAds) has long been considered a promising biotherapeutic agent against various types of cancer owing to selectively replicate in and lyse cells, while remaining dormant healthy cells. In the last years, multiple (pre)clinical studies using genetic engineering technologies enhanced OAds anti-tumor effects broad range cancers. However, poor targeting delivery, tropism toward tissues, low-level expression Ad receptors on tumor pre-existing neutralizing antibodies are major hurdles for systemic administration OAds. Different vehicles have developed addressing these obstacles, such as stem nanoparticles (NPs) shielding polymers, extracellular vesicles (EVs), hydrogels, microparticles (MPs). These carriers can enhance therapeutic efficacy OVs through enhancing transfection, circulatory longevity, cellular interactions, specific targeting, immune responses cancer. this paper, we reviewed structure biology, different OAds,