Regulatory T cells and human disease.
作者： Shimon Sakaguchi , Norihisa Mikami , James B Wing , Atsushi Tanaka , Kenji Ichiyama
DOI: 10.1155/2007/89195
关键词:
摘要: Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a functionally distinct T cell subpopulation actively engaged in the maintenance of immunological self-tolerance and homeostasis. Recent studies have facilitated our understanding of the cellular and molecular basis of their generation, function, phenotypic and functional stability, and adaptability. It is under investigation in humans how functional …
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