Pharmacogenomics in colorectal cancer

作者: H LENZ

DOI: 10.1016/S0093-7754(03)00405-6

关键词:

摘要: Abstract The goal in administering chemotherapeutics is to develop the ability predict outcome of therapy terms response and toxicity. Technology has been developed allow tumor profiling with measurement protein expression gene levels markers even genetic polymorphisms that may particular chemotherapeutics. for which have shown include fluoropyrimidines platinums. next step clinical trials will prospectively assess benefits a patient’s tumor, should translate into an improvement

参考文章(49)
Tsao-Wei D, Stoehlmacher J, Groshen S, Lenz Hj, Iobal S, Ghaderi, Park D, A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. Anticancer Research. ,vol. 21, pp. 3075- 3079 ,(2001)
Bengt Mannervik, The Isoenzymes of Glutathione Transferase Advances in Enzymology - and Related Areas of Molecular Biology. ,vol. 57, pp. 357- 417 ,(2006) , 10.1002/9780470123034.CH5
T. J. Triche, P. Terrier, J. M. Coindre, A. J. Townsend, K. H. Cowan, An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue. American Journal of Pathology. ,vol. 137, pp. 845- 853 ,(1990)
Robert B. Diasio, Glen D. Heggie, Jean-Pierre Sommadossi, David S. Cross, William J. Huster, Clinical Pharmacokinetics of 5-Fluorouracil and Its Metabolites in Plasma, Urine, and Bile Cancer Research. ,vol. 47, pp. 2203- 2206 ,(1987)
Fred F. Kadlubar, Soheila Korourian, Patricia A. Thompson, Angie Stone, Brian F. Coles, Carol Sweeney, Gail Y. McClure, Manal Y. Fares, Christine B. Ambrosone, Laura F. Hutchins, Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer. Cancer Research. ,vol. 61, pp. 7130- 7135 ,(2001)
Peter V. Danenberg, Jan Brabender, Ann L. Jackman, G. Wynne Aherne, David Cunningham, Kathleen D. Danenberg, Anthea Hardcastle, Hugo E. R. Ford, A. David McVicar, Keith McCarthy, David C. Farrugia, Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed. Clinical Cancer Research. ,vol. 9, pp. 792- 801 ,(2003)
C G Leichman, H J Lenz, L Leichman, K Danenberg, J Baranda, S Groshen, W Boswell, R Metzger, M Tan, P V Danenberg, Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. Journal of Clinical Oncology. ,vol. 15, pp. 3223- 3229 ,(1997) , 10.1200/JCO.1997.15.10.3223
E Kanehira, K Omura, K Kawakami, Y Watanabe, Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers Anticancer Research. ,vol. 19, pp. 3249- 3252 ,(1999)