Consequences of intrastriatally administrated FeCl3 and 6-OHDA without and after transient cerebral oligemia on behaviour and navigation

摘要: 6-OHDA (6 or 8 µg) unilaterally applied into the ventrolateral striatum induces neurotoxic effects which lead to unilateral hyperactivity triggering contralateral turning and rotations after apomorphine administration. Treatment with alpha-tocopherol prevents hypersensitive reaction. The sensitivity of cerebral tissue following treatment is enhanced when 7.5 µg FeCl3 coadministered 6-OHDA. Only combination administered escape latency find a hidden platform in water maze-test increased as measured 12 weeks later. night activity such treated animals was markedly reduced. Remarkable (0.06–1.5 ug) were observed old rats, rats transient oligemia. Apomorphine induced rotations. It possible, therefore, that mild moderate permanent local oxygen deficits together iron cause progressive damage vulnerable tissue. Such an effect would be comparable neurotoxicity possibly involve free radicals lipid peroxidation.