Role of P-Glycoprotein and Organic Anion Transporting Polypeptides in Drug Absorption and Distribution Focus on H1-Receptor Antagonists
作者： Philip D. Hansten , Rene H. Levy
DOI: 10.2165/00044011-200121080-00008
关键词:
摘要: Traditionally, drug-induced changes in cytochrome P450 isoenzyme activity, causing drug metabolism and bioavailability, have been the main focus of interaction studies. Recent research, however, suggests that transporters P-glycoprotein organic anion transporting peptide (OATP), which can effect efflux influx many classes drugs, may contribute to interactions by mechanisms independent oxidative metabolism. Experimental models designed selectively probe function or OATP demonstrated activities these a significant on bioavailability clinically important leading potential for adverse interactions.
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