Classification of deaths after myocardial infarction as arrhythmic or nonarrhythmic (the Cardiac Arrhythmia Pilot Study).

摘要: Abstract The Cardiac Arrhythmia Pilot Study (CAPS) was a randomized, double-blind trial of antiarrhythmic drugs (encainide, flecainide, moricizine, imipramine and placebo) in 502 patients with at least 10 ventricular premature complexes/hour, 6 to 60 days after acute myocardial infarction. CAPS tested the feasibility performing larger study determine if suppression ectopic activity infarction could improve survival. Patients were followed for 1 year. All death or cardiac arrest events evaluated by 2 investigators using classification scheme that characterized underlying mechanism as arrhythmic, nonarrhythmic noncardiac. Forty-five (9%) died had during 1-year follow-up, 29 (64%) within hour from onset symptoms 16 > symptoms. Twenty-three deaths (51%) classified 19 (42%) 3 (7%) Acute ischemia associated death/cardiac event (36%), 8 arrhythmic group. Discrepancies among reviewers particularly common long-standing congestive heart failure, whom it frequently difficult identify precise moment event. Using only temporal relation categorize arrests, 12 (27%) 45 disagreement based on Events Committee review. Classification sudden nonsudden is not equivalent nonarrhythmic.