Imaging of P glycoprotein function in vivo with PET.

摘要: P glycoprotein (Pgp) is expressed on cell membranes of various organs in the body, such as capillary endothelial cells brain. Furthermore, Pgp can also be membrane tumour cells. Because Pgp-mediated efflux, tissue levels several substrates are lower than Pgp-negative tissues. Drug Pgp-expressing may increased by modulation this Pgp-facilitated transport with compounds, cyclosporin A. Up to now, presence drug efflux pumps tissues could only examined at mRNA and protein level. However, gives no insight into important question functionality these pumps. Information about function effect modulating improve therapeutic treatment patients. Positron emission tomography (PET) us a unique opportunity study non-invasively (patho)physiological dynamic processes vivo. We have therefore developed validated method for studying its vivo PET.