Induction of calcium-independent nitric oxide synthase by allergen challenge in sensitized rat lung in vivo
作者： Michael Yeadon , Robert Price
DOI: 10.1111/J.1476-5381.1995.TB17204.X
关键词:
摘要: There is some evidence that nitric oxide synthase (NOS) induced in the lungs of patients with allergic asthma, but mechanism this not understood. The aim present study was to investigate whether levels NOS rat lung could be altered by exposure animals aerosols allergen (ovalbumin). Brown-Norway rats were actively sensitized ovalbumin, raising a mixed IgE/IgG antibody response. total and calcium-independent tissue homogenates elevated at 6 h 24 after unsensitized rats. induction due contaminating lipopolysaccharide challenge solution. allergen-induced increase inhibited pretreatment corticosteroid betamethasone (3 mg kg-1 i.p., 1 prior allergen). These results show induces rats, process an anti-inflammatory corticosteroid.
sci-hub.se 参考文章(9)
D M Kemeny, D Diaz-Sanchez, Generation of a long-lived IgE response in high and low responder strains of rat by co-administration of ricin and antigen. Immunology. ,vol. 72, pp. 297- 303 ,(1991)
R G Knowles, S Moncada, Nitric oxide synthases in mammals. Biochemical Journal. ,vol. 298, pp. 249- 258 ,(1994) , 10.1042/BJ2980249
Mark Salter, Richard G. Knowles, Salvador Moncada, Widespread tissue distribution, species distribution and changes in activity of Ca2+
-dependent and Ca2+
-independent nitric oxide synthases FEBS Letters. ,vol. 291, pp. 145- 149 ,(1991) , 10.1016/0014-5793(91)81123-P
Q Hamid, DR. Springall, JM Polak, V Riveros-Moreno, P Chanez, J Bousquet, Philippe Godard, S Holgate, P Howarth, A Redington, Induction of nitric oxide synthase in asthma The Lancet. ,vol. 342, pp. 1510- 1513 ,(1993) , 10.1016/S0140-6736(05)80083-2
D.D. Rees, F.Q. Cunha, J. Assreuy, A.G. Herman, S. Moncada, Sequential induction of nitric oxide synthase by Corynebacterium parvum in different organs of the mouse. British Journal of Pharmacology. ,vol. 114, pp. 689- 693 ,(1995) , 10.1111/J.1476-5381.1995.TB17193.X
Magnus G. Persson, Tore Midtvedt, Anna M. Leone, Lars E. Gustafsson, Ca2+-dependent and Ca2+-independent exhaled nitric oxide, presence in germ-free animals, and inhibition by arginine analogues European Journal of Pharmacology. ,vol. 264, pp. 13- 20 ,(1994) , 10.1016/0014-2999(94)90629-7
Jean Michel Mencia-Huerta, Bernard Dugas, Elisabeth Boichot, Corinne Petit-Frère, Nathalie Paul-Eugène, Vincent Lagente, Monique Capron, Fu-Tong Liu, Pierre Braquet, Pharmacological Modulation of the Antigen-Induced Expression of the Low-Affinity IgE Receptor (FcεRII/CD23) on Rat Alveolar Macrophages International Archives of Allergy and Immunology. ,vol. 94, pp. 295- 298 ,(1991) , 10.1159/000235389
D.D. Rees, S. Cellek, R.M.J. Palmer, S. Moncada, Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochemical and Biophysical Research Communications. ,vol. 173, pp. 541- 547 ,(1990) , 10.1016/S0006-291X(05)80068-3
Nathalie Paul-Eugène, Jean-Pierre Kolb, Marika Sarfati, Michel Arock, Fateh Ouaaz, Patrice Debré, Djavad M. Mossalayi, Bernard Dugas, Ligation of CD23 activates soluble guanylate cyclase in human monocytes via an L-arginine-dependent mechanism. Journal of Leukocyte Biology. ,vol. 57, pp. 160- 167 ,(1995) , 10.1002/JLB.57.1.160