Differential Down-Regulation of the UDP-Glucuronosyltransferase 1A Locus Is an Early Event in Human Liver and Biliary Cancer

摘要: One of the most important processes controlling cellular detoxification is carried out in endoplasmic reticulum by glucuronidation, and likely plays an role defense mechanism against chemical-induced carcinogenesis. The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12 unique transferases that are transcribed through selective exon sharing. Little known about how this regulated tissues. We present evidence gene products differentially expressed normal liver tissue, which composed hepatocellular biliary as well malignant premalignant tumor tissue. In liver, UGT1A1, UGT1A3, UGT1A4, UGT1A9 expressed, all significantly down-regulated carcinoma its precursor, hepatic adenoma, but not benign focal nodular hyperplasia. UGT1A6, abundantly tumors. UGT1A10, a newly discovered product, only tissue also cholangiocellular carcinoma. Differential regulation between observed with UGT1A4. These findings implicate putative early event hepatocarcinogenesis discriminates hepatotumorigenesis indicates complex mode control underlies locus.