Acceleration of activation and inactivation by the β subunit of the skeletal muscle calcium channel
作者： Gyula Varadi , Philippe Lory , David Schultz , Maria Varadi , Arnold Schwartz
DOI: 10.1038/352159A0
关键词:
摘要: THE L-type voltage-dependent calcium channel is an important link in excitation-contraction coupling of muscle cells1 (reviewed refs 2 and 3). The has two functional characteristics: permeation receptor sites for antagonists. In skeletal the a complex five subunits, α1, α2, β, γ δ (ref. 4). Complementary DNAs to these subunits have been cloned their amino-acid sequences deduced5–8. α1 subunit cDNA expressed L cells manifests as specific calcium-ion permeation, well sensitivity three classes organic calcium-channel blockers9,10. We report here that coexpression with other results significant changes dihydropyridine binding gating properties. available number drug increases 10-fold β combination, whereas affinity site remains unchanged. Also, presence accelerates activation inactivation kinetics current.
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