Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function.
作者： Emma K. Persson , Charlotte L. Scott , Allan McI. Mowat , William W. Agace
关键词:
摘要: The intestinal mucosa is exposed to large amounts of foreign antigen (Ag) derived from commensal bacteria, dietary Ags, and pathogens. Dendritic cells (DCs) are believed be involved in the induction tolerance harmless Ags mounting protective immune responses pathogens and, as such, play key roles regulating homeostasis. characterization classical DCs (cDCs) lamina propria has been under intense investigation recent years but use markers (including CD11c, CD11b, MHC class II), which also expressed by MΦs, led some controversy regarding their definition. Here we review studies that help distinguish cDCs subsets monocyte-derived mucosa. We address phenotype ontogeny these cDC highlight findings indicating distinct regulation mucosal vivo.
mendeley.com参考文章(89)
Annabell Bachem, Evelyn Hartung, Steffen Güttler, Ahmed Mora, Xuefei Zhou, Anika Hegemann, Maud Plantinga, Elisa Mazzini, Patrizia Stoitzner, Stephanie Gurka, Volker Henn, Hans W. Mages, Richard A. Kroczek, Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation Frontiers in Immunology. ,vol. 3, pp. 214- 214 ,(2012) , 10.3389/FIMMU.2012.00214
Reinhold Förster, Andreas Schubel, Dagmar Breitfeld, Elisabeth Kremmer, Ingrid Renner-Müller, Eckhard Wolf, Martin Lipp, CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. ,vol. 99, pp. 23- 33 ,(1999) , 10.1016/S0092-8674(00)80059-8
Jeremiah R. McDole, Leroy W. Wheeler, Keely G. McDonald, Baomei Wang, Vjollca Konjufca, Kathryn A. Knoop, Rodney D. Newberry, Mark J. Miller, Goblet cells deliver luminal antigen to CD103 + dendritic cells in the small intestine Nature. ,vol. 483, pp. 345- 349 ,(2012) , 10.1038/NATURE10863
Melissa A. Kinnebrew, Charlie G. Buffie, Gretchen E. Diehl, Lauren A. Zenewicz, Ingrid Leiner, Tobias M. Hohl, Richard A. Flavell, Dan R. Littman, Eric G. Pamer, Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense Immunity. ,vol. 36, pp. 276- 287 ,(2012) , 10.1016/J.IMMUNI.2011.12.011
Ehud Zigmond, Chen Varol, Julia Farache, Elinor Elmaliah, Ansuman T. Satpathy, Gilgi Friedlander, Matthias Mack, Nahum Shpigel, Ivo G. Boneca, Kenneth M. Murphy, Guy Shakhar, Zamir Halpern, Steffen Jung, Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity. ,vol. 37, pp. 1076- 1090 ,(2012) , 10.1016/J.IMMUNI.2012.08.026
Craig L. Maynard, Casey T. Weaver, Intestinal effector T cells in health and disease. Immunity. ,vol. 31, pp. 389- 400 ,(2009) , 10.1016/J.IMMUNI.2009.08.012
Naomi McGovern, Pearline Teo, Teresa Zelante, Koji Atarashi, Donovan Low, Adrian W.S. Ho, Peter See, Amanda Shin, Pavandip Singh Wasan, Guillaume Hoeffel, Benoit Malleret, Alexander Heiseke, Samantha Chew, Laura Jardine, Harriet A. Purvis, Catharien M.U. Hilkens, John Tam, Michael Poidinger, E. Richard Stanley, Anne B. Krug, Laurent Renia, Baalasubramanian Sivasankar, Lai Guan Ng, Matthew Collin, Paola Ricciardi-Castagnoli, Kenya Honda, Muzlifah Haniffa, Florent Ginhoux, Andreas Schlitzer, IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses Immunity. ,vol. 38, pp. 970- 983 ,(2013) , 10.1016/J.IMMUNI.2013.04.011
M Svensson, B Johansson-Lindbom, F Zapata, E Jaensson, L M Austenaa, R Blomhoff, W W Agace, Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8 + T cells Mucosal Immunology. ,vol. 1, pp. 38- 48 ,(2008) , 10.1038/MI.2007.4
Usriansyah Hadis, Benjamin Wahl, Olga Schulz, Matthias Hardtke-Wolenski, Angela Schippers, Norbert Wagner, Werner Müller, Tim Sparwasser, Reinhold Förster, Oliver Pabst, Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria Immunity. ,vol. 34, pp. 237- 246 ,(2011) , 10.1016/J.IMMUNI.2011.01.016
Miriam Merad, Markus G. Manz, Dendritic cell homeostasis Blood. ,vol. 113, pp. 3418- 3427 ,(2009) , 10.1182/BLOOD-2008-12-180646