Idiotype-directed interactions during ontogeny play a major role in the establishment of the adult B cell repertoire.
作者： John F. Kearney , Meenal Vakil
DOI: 10.1111/J.1600-065X.1986.TB01163.X
关键词:
摘要: IgM hybridomas derived from perinatal B cells show a high degree of auto-reactivity and many had demonstrable anti-idiotypic reactivities by binding studies. Selected multispecific antibodies were also shown to have potent idiotype-specific biological activities if administered at appropriate stages development could dramatically alter the responses these mice when challenged with antigens in adult life. The results obtained suggest that idiotype-directed interactions between neonatal play an important role early establishment cell repertoire which is subsequently expressed mice.
sci-hub.se 参考文章(26)
Kathryn E. Stein, Constantin Bona, James J. Mond, Shirley House, Rose Lieberman, William E. Paul, Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny. Journal of Immunology. ,vol. 123, pp. 1484- 1490 ,(1979)
P Lymberi, S Avrameas, G Dighiero, J C Mazié, G S Butler-Browne, R G Whalen, S Rouyre, Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. Journal of Immunology. ,vol. 131, pp. 2267- 2272 ,(1983)
R Stohrer, J Kearney, Ontogeny of B cell precursors responding to alpha 1- greater than 3 dextran in BALB/c mice. Journal of Immunology. ,vol. 133, pp. 2323- 2326 ,(1984)
George D. Yancopoulos, Stephen V. Desiderio, Michael Paskind, John F. Kearney, David Baltimore, Frederick W. Alt, Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. ,vol. 311, pp. 727- 733 ,(1984) , 10.1038/311727A0
Leonore A. Herzenberg, Alan M. Stall, Paul A. Lalor, Charles Sidman, Wayne A. Moore, David R. Parks, Leonard A. Herzenberg, The LY‐1B Cell Lineage Immunological Reviews. ,vol. 93, pp. 81- 102 ,(1986) , 10.1111/J.1600-065X.1986.TB01503.X
David S. Strayer, Heinz Köhler, Immune response to phosphorylcholine ii, natural 'auto'-anti-receptor antibody in neonatal balb/c mice. Cellular Immunology. ,vol. 25, pp. 294- 301 ,(1976) , 10.1016/0008-8749(76)90119-2
John F. Kearney, Raul Barletta, Zoe S. Quan, José Quintáns, Monoclonal vs. heterogeneous anti-H-8 antibodies in the analysis of the anti-phosphorylcholine response in BALB/c mice. European Journal of Immunology. ,vol. 11, pp. 877- 883 ,(1981) , 10.1002/EJI.1830111106
K. Hayakawa, R. R. Hardy, M. Honda, L. A. Herzenberg, A. D. Steinberg, L. A. Herzenberg, Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 2494- 2498 ,(1984) , 10.1073/PNAS.81.8.2494
GARNETT KELSOE, JAN CERNY, Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. Nature. ,vol. 279, pp. 333- 334 ,(1979) , 10.1038/279333A0
PETER BURROWS, MARK LEJEUNE, JOHN F. KEARNEY, Evidence that murine pre-B cells synthesise μ heavy chains but no light chains Nature. ,vol. 280, pp. 838- 841 ,(1979) , 10.1038/280838A0