Structural and functional changes in the skeletal muscles of COPD patients: the "compartments" theory.

摘要: This review focuses on the structural and functional changes occurring in respiratory as well peripheral muscles COPD patients. These are particular for each muscle territory or compartment. Respiratory predominantly undergo adaptive changes. However, they have to do their job unfavourable mechanical conditions thus function is impaired. Peripheral be grouped at least two different compartments: upper lower limb muscles. The structure relatively preserved former, due maintenance of some daily activities involving arms even use these ventilatory effort. Lower contrast involute which result an impairment global exercise capacity individual. Deconditioning a reduction secondary probably driving factor Although level activity appears main determining territories, this would modulated by other local systemic factors, such inflammation, oxidative stress, drugs nutritional abnormalities.