Ubiquitin–Proteasome System in the Hallmarks of Cancer

摘要: The paramount role of ubiquitin–protein conjugation for its ability to regulate protein turnover and nonproteolytic signaling functions has been implicated in the regulation various biological pathological phenomena. Malignant cells utilize modified ubiquitination augment or attenuate pathways on basis whether outcome this is conducive not tumor growth survival. Hence, there lies a necessity fresh view at ubiquitin-dependent mechanisms that play an important human oncological diseases. To control ubiquitination-dependent cell transformation within themselves, along with increased rate synthesis, translation quality processes are often required support transforming events their contribution progression. Given ubiquitin metabolism governed by enzymes—E1, E2, E3, E4, deubiquitinases (DUBs), proteasome—the system as whole ripe target drug discovery cancer. Recently, hallmarks cancer designated Hanahan Weinberg 2011 comprise ten capabilities acquired during multistep development tumor. Based these hallmarks, present review enlightened every hallmark rationalizing complexities neoplastic disease also discusses therapeutic implications targeting ubiquitin–proteasome well synthetic natural compounds potent inhibitory effects.