Molecular assays for surveillance of antifolate-resistant malaria
作者： James G Kublin , Richard S Witzig , Anuraj H Shankar , Jorge Quintana Zurita , Robert H Gilman
DOI: 10.1016/S0140-6736(98)24022-0
关键词:
摘要: to detect all known DHFR and DHPSmutations, correlations were determined betweenDHFR DHPS genotypes therapeutic responsedefined as sensitive (S), RI, RII, or RIII resistance.A genotype defined by mutations Asn-108, Ile-51,and Leu-164 combined with Gly-437,Glu-540, Gly-581 was detected in 7/8 cases (87·5%) ofRIII resistance, 9/13 (69·2%) of RII 5/13cases (38·5%) RI 0/11 cases(0·0%) (figure). The Bolivia repeat mutation at codon 30,
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