Adenosine Receptors in Modulation of Central Nervous System Disorders.

摘要: The ubiquitous signaling nucleoside molecule, adenosine is found in different cells of the human body to provide its numerous pharmacological role. associated actions endogenous are largely dependent on conformational change widely expressed heterodimeric G-protein-coupled A1, A2A, A2B, and A3 receptors (ARs). These well conserved surface specific cells, where potent neuromodulatory properties this bioactive molecule reflected by easy passage through rigid blood-brainbarrier, simultaneously act central nervous system (CNS). minimal concentration fluids (30-300 nM) adequate exert action CNS, whereas modulatory effect ARs consequence several neurodegenerative diseases. Modulatory concerning activation such CNS could be facilitated towards neuroprotective against disorders. Our aim herein discuss briefly pathophysiological roles modulation disorders, which focused identification potential drug targets recovering accompanying Researches with active components AR have been extended already reached bedside patients clinical research improvement Therefore, review consist recent findings literatures impact diverse disease pathways possible relevance neurodegeneration.