Role of Hsp27 and Related Proteins

摘要: Investigations of the cellular response to thermal and other types stresses have allowed identification families proteins (the heat shock or stress proteins, Hsp) whose expression is enhanced when environmental conditions become deleterious (reviewed in Georgopoulos Welch 1993; Morimoto et al. 1994). Hsp are subdivided two groups, based on their apparent molecular mass, i.e., large small proteins. Small now denoted (sHsp), characterized by a domain homology aA,B-crystallin from vertebrate eye Arrigo Landry Despite this particular homology, sHsp less conserved than (i.e., Hsp70) since, among species, they show greater variations sequence, number mass. All analyzed so far share extreme tendency form oligomers. Like a-crystallin, aggregates with heterodispersed native masses (which can reach up 800 kDa more). This structural organization depends physiology cell probably also phosphorylation these (Siezen 1978a; 1987; 1988; Kato 1994; Lavoie 1995; Mehlen 1995b,c).