Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population.

摘要: Background: Low serum 25-hydroxyvitamin D [25(OH)D] concentrations during pregnancy have been associated with adverse outcomes in a few studies but not other studies. Objectives: We assessed the 25(OH)D concentration at 10– 14 wk and its association examined predictive accuracy. Design: In this nested case-control study, we measured 5109 women singleton pregnancies who were attending first-trimester screening New South Wales, Australia. Multivariate logistic regression was conducted to examine between low (small for gestational age, preterm birth, preeclampsia, diabetes, miscarriage, stillbirth). The accuracy of models assessed. Results: median (IQR) total population 56.4 nmol/L (43.3–69.8 nmol/L). Serum showed significant variation by parity, smoking, weight, season sampling, country socioeconomic status. After adjustment maternal clinical risk factors, most outcomes. area under receiver operating characteristic curve (AUC) likelihood ratio composite severe ,25 0.51 1.44, respectively, and, factors alone, 0.64 2.87, respectively. addition information did improve ability predict (AUC: 0.64; ratio: 2.32; P = 0.39). Conclusion: first trimester are do complications any better than routinely risk-factor information. Am J Clin Nutr doi: 10.3945/ajcn.113.065672.