The Role of CD1d and MR1 Restricted T Cells in the Liver.

摘要: The liver is one of the most important immunological organs that remains tolerogenic in homeostasis yet promotes rapid responses to pathogens presence a systemic infection. composition leucocytes highly distinct from blood and other lymphoid organs, particularly with respect enrichment innate T cells, i.e., invariant NKT cells (iNKT cells) Mucosal-Associated Invariant (MAIT cells). In recent years, studies have revealed insights into their biology potential roles maintaining immune-environment liver. As primary liver-resident immune they are emerging as significant players human system associated an increasing number clinical diseases. such, promising targets for modifying host defense inflammation various diseases, including viral, autoimmune, those tumor origin. this review, we emphasize discuss some discoveries advances recruitment diversity liver, role postulating on application immunotherapy.