The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities

摘要: To evaluate the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) its effect on survival in patients with unresectable huge hepatocellular carcinoma (HCC) unsuitable other standard treatment option. Between 2009 2011, 22 HCC (≧10 cm) were treated SBRT. dose ranged from 26 Gy to 40 Gy five fractions. Overall (OS) disease-progression free (DPFS) determined by Kaplan-Meier analysis. Tumor response toxicities also assessed. After a median follow-up 11.5 month (range 2–46 months). The objective rate was achieved 86.3% (complete (CR): 22.7% partial (PR): 63.6%). 1-yr. local control 55.56%. 1-year OS 50% 11 months In univariate analysis, Child-Pugh stage (p = 0.0056) SBRT (p = 0.0017) significant factors for survival. However, multivariate (p = 0.0072) most factor, while borderline significance. (p = 0.0514). Acute mild well tolerated. This study showed that can be delivered safely substantial tumor regression results suggest this technique should considered salvage treatment. regional recurrence remain major cause failure. Further studies combination modalities may reasonable.