Oxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets.
作者： Michel Lagarde , Michel Guichardant , Nathalie Bernoud-Hubac , Catherine Calzada , Evelyne Véricel
DOI: 10.1016/J.BBALIP.2018.03.005
关键词:
摘要: The oxygenation metabolism of arachidonic acid (ArA) has been early described in blood platelets, particular with its conversion into the potent labile thromboxane A2 that induces platelet aggregation and vascular smooth muscle cells contraction. In addition, primary prostaglandins D2 E2 have mainly reported as inhibitors function. 12-lipoxygenase (12-LOX) product, i.e. hydroperoxide 12-HpETE, appears to stimulate ArA at level release from membrane phospholipids through phospholipase (cPLA2) cyclooxygenase (COX-1) activities, first enzymes prostanoid production cascade. Also, 12-HpETE may regulate other polyunsaturated fatty acids (PUFA) by especially eicosapentaenoic (EPA). On hand, reduced product 12-HETE, is able antagonize TxA2 action. This even more obvious for 12-LOX end-products docosahexaenoic (DHA), 11- 14-HDoHE. plays a key role oxidative stress observed pathophysiological conditions, but be regulated DHA bimodal way according concentration. Other oxygenated products PUFA, omega-3 produced outside platelets affect functions well.
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