作者: G. Matera , M. Chisari , D. Altavilla , A. Foca , J. A. Cook
DOI: 10.3181/00379727-187-42637
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摘要: The efficacy of N,N'-bis-(3-picolyl)-methoxyisophthalamide (picotamide) as an in vitro thromboxane synthetase inhibitor and its effect on endotoxin (LPS)-induced lethality rats were assessed. Picotamide at 0.5 1.0 mM concentrations significantly (P less than 0.05) inhibited basal LPS-stimulated synthesis TxA2 measured by stable immunoreactive (i) metabolite TxB2 rat peritoneal macrophages. This compound did not inhibit i6-keto-PGF1 alpha, the PGI2, produced significant shunting to alpha. For studies pretreated, gavage with picotamide, either 75, 150, 300, or 600 mg/kg 2 hr prior iv S. enteritidis (LPS, 20 mg/kg). Both 150 300 doses picotamide improved survival shock 48 hr. These demonstrate that is a selective inhibitor, it may be useful during disease states characterized increased synthesis.