“Power frequency fields promote cell differentiation coincident with an increase in transforming growth factor‐b1 expression”

摘要: Recent information from several laboratories suggest that power frequency fields may stimulate cell differentiation in a number of model systems. In this way, they be similar to pulsed electromagnetic fields, which have been used therapeutically. However, the effects on phenotypic or genotypic expression not explained. This study describes ability accelerate vivo and dose relationships terms both amplitude exposure duration. No change proliferation content were observed. A clear relationship, duration exposure, was determined with maximal biological response occurring at 0.1 mT 7–9 h/day. Because designed explore activity environmental levels, range does necessarily define optimal dosing conditions therapeutic point view. reports stimulation by transforming growth factor-β, an important signalling cytokine known regulate differentiation. The hypothesis is raised regulatory cytokines intermediary mechanism these their activity. Bioelectromagnetics 20:453–458, 1999. © 1999 Wiley-Liss, Inc.