Redox-based endoplasmic reticulum dysfunction in neurological diseases
作者： Gábor Bánhegyi , József Mandl , Miklós Csala
DOI: 10.1111/J.1471-4159.2008.05571.X
关键词:
摘要: The redox homeostasis of the endoplasmic reticulum lumen is characteristically different from that other subcellular compartments. concerted action membrane transport processes and oxidoreductase enzymes maintain oxidized state thiol-disulfide reducing pyridine nucleotide systems, which are prerequisites for normal functions organelle. powerful thiol-oxidizing machinery allows oxidative protein folding but continuously challenges local antioxidant defense. Alterations cellular environment either in oxidizing or direction affect processing may induce stress unfolded response. activated signaling pathways attempt to restore balance between loading apoptosis if fails. Recent findings strongly support involvement this mechanism brain ischemia, neuronal degenerative diseases traumatic injury. changes integral parts pathomechanism neurological diseases, as causative agents, complications.
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