Evidence for autosomal dominant transmission in Tourette's syndrome. United Kingdom cohort study.

摘要: Complex segregation analyses were performed on families ascertained through 40 unselected consecutive patients with Tourette's syndrome to examine the hypothesis that its transmission is consistent genetic inheritance. Analyses done using several diagnostic classifications. All results an autosomal dominant gene high penetrance. The penetrances ranged from 0.882 1.000 for males and 0.452 0.980 females, depending upon specific classification scheme incorporated into analyses.