Final steps of natural killer cell maturation: a model for type 1–type 2 differentiation?
作者： Matthew J. Loza , Bice Perussia
DOI: 10.1038/NI1001-917
关键词:
摘要: Analysis of cytokine and differentiation antigen expression in human natural killer (NK) cells revealed that interleukin 13 (IL-13) interferon γ (IFN-γ) are produced at sequential stages during irreversible IL-12–induced differentiation. In NK cell clones, polyclonal CD3−CD161+CD56− peripheral lymphocytes, IL-4 induced the proliferation both IL-13+ T cells, whereas IL-12 allowed a proliferation-independent accumulation IFN-γ+ cells. These data disproved NK1-NK2 hypothesis challenge current helper 1 (TH1)-TH2 paradigm. We propose environment regulates type 2→0→1 developmental progression, with needed for terminal delaying this process, rather than versus 2 decision 0 cell.
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sci-hub.se 参考文章(33)
K. M. Murphy, W. Ouyang, S. J. Szabo, N. G. Jacobson, M. L. Guler, J. D. Gorham, U. Gubler, T. L. Murphy, T Helper Differentiation Proceeds Through Stat1-Dependent, Stat4-Dependent and Stat4-Independent Phases Current Topics in Microbiology and Immunology. ,vol. 238, pp. 13- 26 ,(1999) , 10.1007/978-3-662-09709-0_2
V Fanning, S Starr, B Perussia, S Abraham, G Trinchieri, Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1 Journal of Immunology. ,vol. 130, pp. 2133- 2141 ,(1983)
Livio Azzoni, Kristin A. Puorro, Marino Paroli, Laurence C. Eisenlohr, Bice Perussia, Rossana Trotta, Bekele Abebe, Dependence of Both Spontaneous and Antibody-Dependent, Granule Exocytosis-Mediated NK Cell Cytotoxicity on Extracellular Signal-Regulated Kinases Journal of Immunology. ,vol. 161, pp. 6648- 6656 ,(1998)
D Santoli, K Tsuji, A D'Andrea, B Perussia, S F Wolf, S H Chan, M Pospisil, G Trinchieri, D Young, Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. Journal of Immunology. ,vol. 149, pp. 3495- 3502 ,(1992)
V Fanning, B Perussia, G Trinchieri, A human NK and K cell subset shares with cytotoxic T cells expression of the antigen recognized by antibody OKT8. Journal of Immunology. ,vol. 131, pp. 223- 231 ,(1983)
C Taswell, Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. Journal of Immunology. ,vol. 126, pp. 1614- 1619 ,(1981)
Susanne J Szabo, Sean T Kim, Gina L Costa, Xiankui Zhang, C.Garrison Fathman, Laurie H Glimcher, A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. ,vol. 100, pp. 655- 669 ,(2000) , 10.1016/S0092-8674(00)80702-3
Tamotsu Ishizuka, Ichiro Hirata, Masakazu Adachi, Fumihiko Kurimoto, Takeshi Hisada, Kunio Dobashi, Masatomo Mori, Effects of interferon-? on cell differentiation and cytokine production of a human monoblast cell line, U937 Inflammation. ,vol. 19, pp. 627- 636 ,(1995) , 10.1007/BF01534567
Noelle Sevilir Williams, Thomas A. Moore, John D. Schatzle, Igor J. Puzanov, P.V. Sivakumar, Albert Zlotnik, Michael Bennett, Vinay Kumar, Generation of Lytic Natural Killer 1.1+, Ly-49− Cells from Multipotential Murine Bone Marrow Progenitors in a Stroma-free Culture: Definition of Cytokine Requirements and Developmental Intermediates Journal of Experimental Medicine. ,vol. 186, pp. 1609- 1614 ,(1997) , 10.1084/JEM.186.9.1609
Mariapia A. Degli-Esposti, Pamela J. Smolak, Henning Walczak, Jennifer Waugh, Chang-Pin Huang, Robert F. DuBose, Raymond G. Goodwin, Craig A. Smith, Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. Journal of Experimental Medicine. ,vol. 186, pp. 1165- 1170 ,(1997) , 10.1084/JEM.186.7.1165