Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury

作者: Guzal Khayrullina , Sara Bermudez , Kimberly R. Byrnes

DOI: 10.1186/S12974-015-0391-8

关键词:

摘要: Background Spinal cord injury (SCI) results in the activation of NADPH oxidase (NOX) enzyme, inducing production reactive oxygen species (ROS). We hypothesized that NOX2 isoform plays an integral role post-SCI inflammation and functional deficits.

参考文章(28)
Sang-Ho Choi, Saba Aid, Hyung-Wook Kim, Sharon H. Jackson, Francesca Bosetti, Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation Journal of Neurochemistry. ,vol. 120, pp. 292- 301 ,(2012) , 10.1111/J.1471-4159.2011.07572.X
Qingshan Wang, Chun-Hsien Chu, Esteban Oyarzabal, Lulu Jiang, Shih-Heng Chen, Belinda Wilson, Li Qian, Jau-Shyong Hong, Subpicomolar Diphenyleneiodonium Inhibits Microglial NADPH Oxidase with High Specificity and Shows Great Potential as a Therapeutic Agent for Neurodegenerative Diseases Glia. ,vol. 62, pp. 2034- 2043 ,(2014) , 10.1002/GLIA.22724
Ahdeah Pajoohesh-Ganji, Susan M. Knoblach, Alan I. Faden, Kimberly R. Byrnes, Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Research. ,vol. 1475, pp. 96- 105 ,(2012) , 10.1016/J.BRAINRES.2012.07.058
S. J. Cooney, Y. Zhao, K. R. Byrnes, CHARACTERIZATION OF THE EXPRESSION AND INFLAMMATORY ACTIVITY OF NADPH OXIDASE AFTER SPINAL CORD INJURY Free Radical Research. ,vol. 48, pp. 929- 939 ,(2014) , 10.3109/10715762.2014.927578
Edwin K Jackson, Delbert G Gillespie, Chongxue Zhu, Jin Ren, Lefteris C Zacharia, Zaichuan Mi, None, α2-Adrenoceptors Enhance Angiotensin II–Induced Renal Vasoconstriction: Role for NADPH Oxidase and RhoA Hypertension. ,vol. 51, pp. 719- 726 ,(2008) , 10.1161/HYPERTENSIONAHA.107.096297
Kimberly R. Byrnes, Jorge Garay, Simone Di Giovanni, Andrea De Biase, Susan M. Knoblach, Eric P. Hoffman, Vilen Movsesyan, Alan I. Faden, Expression of two temporally distinct microglia‐related gene clusters after spinal cord injury Glia. ,vol. 53, pp. 420- 433 ,(2006) , 10.1002/GLIA.20295
Kimberly R Byrnes, David J Loane, Bogdan A Stoica, Jiangyang Zhang, Alan I Faden, Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. Journal of Neuroinflammation. ,vol. 9, pp. 43- 43 ,(2012) , 10.1186/1742-2094-9-43
D. A. Ramsay, G. A. Dekaban, A. E. Marcillo, A. D. Saenz, M. Pasquale-Styles, W. D. Dietrich, L. C. Weaver, J. C. Fleming, M. D. Norenberg, The cellular inflammatory response in human spinal cords after injury. Brain. ,vol. 129, pp. 3249- 3269 ,(2006) , 10.1093/BRAIN/AWL296
Anhui Yao, Fangfang Liu, Kun Chen, Liang Tang, Ling Liu, Kun Zhang, Caiyong Yu, Ganlan Bian, Hongmin Guo, Jingjing Zheng, Peng Cheng, Gong Ju, Jian Wang, Programmed Death 1 Deficiency Induces the Polarization of Macrophages/Microglia to the M1 Phenotype After Spinal Cord Injury in Mice Neurotherapeutics. ,vol. 11, pp. 636- 650 ,(2014) , 10.1007/S13311-013-0254-X
Kimberly R Byrnes, Patricia M Washington, Susan M Knoblach, Eric Hoffman, Alan I Faden, Delayed inflammatory mRNA and protein expression after spinal cord injury Journal of Neuroinflammation. ,vol. 8, pp. 130- 130 ,(2011) , 10.1186/1742-2094-8-130