Generation of pluripotent stem cells without the use of genetic material.
作者： Akon Higuchi , Qing-Dong Ling , S Suresh Kumar , Murugan A Munusamy , Abdullah A Alarfaj
DOI: 10.1038/LABINVEST.2014.132
关键词:
摘要: Induced pluripotent stem cells (iPSCs) provide a platform to obtain patient-specific for use as cell source in regenerative medicine. Although iPSCs do not have the ethical concerns of embryonic cells, been widely used clinical applications, they are generated by gene transduction. Recently, without genetic material. For example, protein-induced PSCs and chemically induced small large (protein) molecules. Several epigenetic characteristics important differentiation; therefore, several small-molecule inhibitors epigenetic-modifying enzymes, such DNA methyltransferases, histone deacetylases, demethylases, potential candidates reprogramming somatic into iPSCs. In this review, we discuss what types chemical or molecules could be replace viral transduction genes and/or human
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