Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals

作者: PS Sachdev , M Valenzuela , XL Wang , JCL Looi , H Brodaty

DOI: 10.1212/WNL.60.7.1220

关键词:

摘要: To the Editor: We read with interest study of Sachdev et al.,1 who reported an association between elevated homocysteine levels and brain atrophy in healthy elderly subjects. our knowledge, this observation is second report about a linkage increased volume reduction. Recently, radiologic evidence temporal progression patients AD has been found to be significant greater among those higher plasma levels.2 In addition these findings we would like emphasize influence chronic alcoholism on alcoholism-related shrinkage. Chronic alcohol consumption leads, other lesions, cortical …

参考文章(26)
Albee Messing, James E. Goldman, Anne B. Johnson, Michael Brenner, Alexander disease: new insights from genetics. Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 563- 573 ,(2001) , 10.1093/JNEN/60.6.563
Michael Brenner, Anne B. Johnson, Odile Boespflug-Tanguy, Diana Rodriguez, James E. Goldman, Albee Messing, Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nature Genetics. ,vol. 27, pp. 117- 120 ,(2001) , 10.1038/83679
I.D. Nicholl, R.A. Quinlan, Chaperone activity of alpha-crystallins modulates intermediate filament assembly. The EMBO Journal. ,vol. 13, pp. 945- 953 ,(1994) , 10.1002/J.1460-2075.1994.TB06339.X
Ebba Nexo, Frode Engbaek, Per Magne Ueland, Christina Westby, Paudy O’Gorman, Carole Johnston, Bengt Frode Kase, Anne B Guttormsen, Ingrid Alfheim, Joseph McPartlin, David Smith, Jan Møller, Karsten Rasmussen, Robert Clarke, John M Scott, Helga Refsum, Evaluation of Novel Assays in Clinical Chemistry: Quantification of Plasma Total Homocysteine Clinical Chemistry. ,vol. 46, pp. 1150- 1156 ,(2000) , 10.1093/CLINCHEM/46.8.1150
Diana Rodriguez, Fernande Gauthier, Enrico Bertini, Marianna Bugiani, Michael Brenner, Sylvie N'guyen, Cyril Goizet, Antoinette Gelot, Robert Surtees, Jean-Michel Pedespan, Xavier Hernandorena, Monica Troncoso, Graziela Uziel, Albee Messing, Gérard Ponsot, Danielle Pham-Dinh, André Dautigny, Odile Boespflug-Tanguy, Infantile Alexander disease: spectrum of GFAP mutations and genotype-phenotype correlation. American Journal of Human Genetics. ,vol. 69, pp. 1134- 1140 ,(2001) , 10.1086/323799
N. Shiroma, N. Kanazawa, M. Izumi, K. Sugai, M. Fukumizu, M. Sasaki, S. Hanaoka, M. Kaga, S. Tsujino, Diagnosis of Alexander disease in a Japanese patient by molecular genetic analysis. Journal of Human Genetics. ,vol. 46, pp. 579- 582 ,(2001) , 10.1007/S100380170024
Yoko Aoki, Kazuhiro Haginoya, Mitsutoshi Munakata, Hiroyuki Yokoyama, Toshiyuki Nishio, Noriko Togashi, Tatsuo Ito, Yoichi Suzuki, Shigeo Kure, Kazuie Iinuma, Michael Brenner, Yoichi Matsubara, A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander disease Neuroscience Letters. ,vol. 312, pp. 71- 74 ,(2001) , 10.1016/S0304-3940(01)02139-5
Stefan Bleich, Detlef Degner, Stefan Kropp, Eckart Rüther, Johannes Kornhuber, Red wine, spirits, beer and serum homocysteine The Lancet. ,vol. 356, pp. 512- ,(2000) , 10.1016/S0140-6736(05)74186-6
Sharon Reutens, Perminder Sachdev, Homocysteine in neuropsychiatric disorders of the elderly. International Journal of Geriatric Psychiatry. ,vol. 17, pp. 859- 864 ,(2002) , 10.1002/GPS.723
Akiko Iwaki, Toru Iwaki, James E. Goldman, Koji Ogomori, Jun Tateishi, Yoshiyuki Sakaki, Accumulation of αB-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5′-flanking and coding sequence of the genomic DNA Neuroscience Letters. ,vol. 140, pp. 89- 92 ,(1992) , 10.1016/0304-3940(92)90689-5