2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC.

摘要: One contributing factor to the loss of T cells in AIDS may be impaired ability cell precursors expand, as reflected a decreased patient form colonies agar. We and others have noted such defect people with ARC, found that suppressor suppressive plasma contribute T-CFC formation. report here reducing agents 2-mercaptoethanol (2-ME) n-acetyl cysteine (NAC) can enhance colony formation vitro. In part, 2-ME reverse colony-forming (T-CFC) by overcoming effect cells. group 46 patients, was initially 42 +/- 8% (mean s.e.) control levels. caused an increase 401 76% which significantly greater than formation; it also enhanced from ARC patients. Suppressor activity ten patients 58 21% 12 10% when added. Similar data were obtained 14 NAC, related antioxidant low toxicity, Vitamin C generally did not The suggest certain antioxidants NAC useful treatment protocols numbers or ARC.