Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.
作者： Tamara Zorbaz , David Malinak , Kamil Kuca , Kamil Musilek , Zrinka Kovarik
DOI: 10.1016/J.CBI.2019.04.020
关键词:
摘要: Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents, were tested in the reactivation butyrylcholinesterase (BChE) sarin, cyclosarin, VX, tabun. A highlighted AChE reactivator, dichlorinated bispyridinium oxime propyl linker (K868), was more detail for four agent-BChE conjugates. Its BChE potency showed be promising when compared standard used medical practice, asoxime (HI-6) pralidoxime (2-PAM), especially case sarin This finding could pseudo-catalytic scavenging most agents due its cumulative capacity reactivate both BChE.
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