Indolizines II: Search for potential oral hypoglycemic agents
作者： A.U. De , B.P. Saha
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摘要: A few 1,2-bis(N-alkylaminomethyl)indolizines, simple indolizinecarboxylic acids, and several 6-alkoxyindolizine-2-carboxylic acids were synthesized screened as possible oral hypoglycemic agents. The absence of any significant activity excludes these compounds from the predicted structural lead provided by some Vinca alkaloids, such vincamine, vindoline, vindolinine, having indolizine ring one component. But an extension rationale that indolizines are also components carcinolytic vincristine vinblastine, used in cancer chemotherapy encouraging results. One derivative showed antineoplastic Ehrlich ascites carcinoma.
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