Ru(II)–DMSO complexes containing aromatic and heterocyclic acid hydrazides: Structure, electrochemistry and biological activity
作者： Viswanathan Mahalingam , Nataraj Chitrapriya , Matthias Zeller , Karuppannan Natarajan
DOI: 10.1016/J.POLY.2009.03.023
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摘要: Abstract The reaction of cis-[RuCl2(DMSO)4] with a family aromatic and heterocyclic acid hydrazides yielded new complexes the general formula trans-[RuCl2(DMSO)2(hydrazide)] · nH2O (n = 0; 1–6; n = 1; 7). have been characterized by IR, UV–Vis 1H NMR spectroscopic methods. In addition, structure one complexes, [RuCl2(DMSO)2(tcah)] · H2O (tcah = thiophene-2-carboxylic hydrazide), has determined single crystal X-ray diffraction. All studies reveal neutral bidentate coordination hydrazide ligands through acyl oxygen amine nitrogen atoms. electron transfer properties were studied cyclic voltammetry all except show an irreversible/quasi-reversible reduction wave (RuII/RuI) uncoupled oxidation peak (RuIII/ RuII). preliminary DNA-binding ability herring sperm DNA, shows binding DNA lesser affinity than classical intercalators. also screened for their antibacterial activity against five pathogenic bacteria.
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sci-hub.se 参考文章(52)
Youxiang Wang, David M. Eichhorn, Niranjan Goswami, Qiaoqin Zhao, D. Paul Rillema, Crystal structure and physical properties of a ruthenium(II) bipyridine dimethylsulfoxide complex Journal of Chemical Crystallography. ,vol. 29, pp. 277- 281 ,(1999) , 10.1023/A:1009513616056
Barbara Cardillo, Elisabetta Giorgini, Eziana Maurelli, Giorgio Tosi, Molecular complexes of hydrazides with copper(II) Monatshefte Fur Chemie. ,vol. 123, pp. 231- 236 ,(1992) , 10.1007/BF00810470
J.A. Davies, The Coordination Chemistry of Sulfoxides with Transition Metals Advances in Inorganic Chemistry and Radiochemistry. ,vol. 24, pp. 115- 187 ,(1981) , 10.1016/S0065-2792(08)60327-1
T. Daniel Thangadurai, M. Gowri, K. Natarajan, SYNTHESIS AND CHARACTERISATION OF RUTHENIUM(III) COMPLEXES CONTAINING MONOBASIC BIDENTATE SCHIFF BASES AND THEIR BIOLOGICAL ACTIVITIES Synthesis and Reactivity in Inorganic and Metal-organic Chemistry. ,vol. 32, pp. 329- 343 ,(2002) , 10.1081/SIM-120003211
Montserrat Rodríguez, Isabel Romero, Antoni Llobet, Alain Deronzier, Margret Biner, Teodor Parella, Helen Stoeckli-Evans, Synthesis, Structure, and Redox and Catalytic Properties of a New Family of Ruthenium Complexes Containing the Tridentate bpea Ligand Inorganic Chemistry. ,vol. 40, pp. 4150- 4156 ,(2001) , 10.1021/IC010064Q
G. Sava, S. Zorzet, T. Giraldi, G. Mestroni, G. Zassinovich, Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms European Journal of Cancer and Clinical Oncology. ,vol. 20, pp. 841- 847 ,(1984) , 10.1016/0277-5379(84)90223-2
Paul J. Dyson, Gianni Sava, Metal-based antitumour drugs in the post genomic era. Dalton Transactions. pp. 1929- 1933 ,(2006) , 10.1039/B601840H
K. Naresh Kumar, R. Ramesh, Synthesis, luminescent, redox and catalytic properties of Ru(II) carbonyl complexes containing 2N2O donors Polyhedron. ,vol. 24, pp. 1885- 1892 ,(2005) , 10.1016/J.POLY.2005.05.020
Adam Wu, David C. Kennedy, Brian O. Patrick, Brian R. James, Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay Inorganic Chemistry. ,vol. 42, pp. 7579- 7586 ,(2003) , 10.1021/IC030119J
Monica Baldini, Marisa Belicchi-Ferrari, Franco Bisceglie, Giorgio Pelosi, Silvana Pinelli, Pieralberto Tarasconi, Cu(II) complexes with heterocyclic substituted thiosemicarbazones: the case of 5-formyluracil. Synthesis, characterization, x-ray structures, DNA interaction studies, and biological activity. Inorganic Chemistry. ,vol. 42, pp. 2049- 2055 ,(2003) , 10.1021/IC026131D