Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis.

摘要: Abstract Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have gained much attention owing to their multiple pharmacological potentials. The present study intends investigate the anti-proliferative anti-inflammatory efficacy of Orientin 1,2-dimethyl hydrazine (DMH) induced colorectal cancer (CRC) rats. Animals were arbitrarily segmented into six groups fed with high-fat diet. Group 1 served as control. 2 received weekly subcutaneous injections DMH (20 mg/kg b.w.), for first 15 weeks. 3 administered (10 mg/kg b.w., i.p.) whereas Groups 4–6 treated three phases, namely initiation (along DMH), post-initiation (post-DMH injection) entire period. ameliorates tumor marker levels significantly (p