Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum

摘要: Clinical manifestations in diseases affecting the dopamine system include deficits emotional, cognitive, and motor function. Although parallel organization of specific corticostriatal pathways is well documented, mechanisms by which might integrate information across different cortical/basal ganglia circuits are less understood. We analyzed a collection retrograde anterograde tracing studies to understand how striatonigrostriatal (SNS) subcircuit directs flow between ventromedial (limbic), central (associative), dorsolateral (motor) striatal regions. When viewed as whole, striatum projects wide range cells receives relatively small input. In contrast, (DLS) input from broad expanse has confined substantia nigra (SN). The (CS) SN. SNS projection each region contains three components: dorsal group nigrostriatal projecting cells, containing both its reciprocal striatonigral terminal fields, ventral that but does not contain projection. Examination results multiple experiments simultaneously demonstrates an interface regions via midbrain forms ascending spiral shell influences core, core striatum, striatum. This anatomical arrangement creates hierarchy provides basis for limbic/cognitive/motor midbrain.