A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals.

摘要: An attenuated Campylobacter jejuni aspartate chemoreceptor ccaA mutant caused gross pathological changes despite reduced colonisation ability in animal models. In chickens, the included connective tissue and thickening of mesenteric fat, as well disintegration villus tips large intestine, whereas mice, hepatomegaly occurred between 48–72 hours post infection persisted for six days time course. addition, there was a significant change levels IL-12p70 mice infected with C. mutant. CcaA isogenic hyper-invasive cell culture microscopic examination revealed that it had “run” bias its “run-and-tumble” chemotactic behaviour. The cells also exhibited lower level binding to fucosylated higher sialylated glycan structures array analysis. This study highlights importance investigating phenotypic jejuni, we have shown specific mutants can cause host, reduction potential.