Evaluation of sustained release aqueous suspensions containing microencapsulated drug-resin complexes

摘要: AbstractCellulose Acetate Butyrate coated resinates released chlorpheniramine faster if the microcapsules were hydrated by suspension prior to release studies when compared dry, unsuspended microcapsules. Contrasting a sulfonic acid resinate with carboxylic showed reduced rate of for from both and uncoated resinates. Microcapsules smaller diameter than larger similar batch. prepared under identical conditions pseudoephedrine, diphenhydramine, at different rates, pseudoephedrine being fastest slowest. Aging aqueous suspensions containing room elevated temperatures resulted in drug profiles which within experimental error.