Glutamate Receptor Autoradiography and in situ Hybridization

摘要: Publisher Summary A large body of evidence indicates that the excitatory amino acid glutamate is most abundant transmitter in hypothalamus and brain general. The (glutamate) receptors consequently have widespread involvement normal CNS functions. However, under extreme conditions these can become potent mediators neurotoxicity. association with neuronal damage extensively documented response to traumatic events such as anoxic–ischemic insults, well disease states epilepsy, Huntington's disease, Alzheimer's , ALS, chronic pain, human immunodeficiency virus infections. Because ubiquitous distribution their prominent role synaptic plasticity, any disturbance function, even absence neurodegeneration would be expected produce a vast array undesirable effects. Glutamate often played pivotal etiology are thought necessary for expression plasticity. Although less known about acute or toxins, it likely play an equally important evolution neurotoxicological changes CNS. This evidenced this chapter by effects naturally occurring receptor neurotoxins side been seen antagonists developed therapeutic purposes. Given both function neurodegenerative evaluation provide insights into impact environmental insults on function.