Bronchoalveolar lavage cytokines are of minor value to diagnose complications following lung transplantation.
作者： Nicole E. Speck , Elisabeth Probst-Müller , Sarah R. Haile , Christian Benden , Malcolm Kohler
DOI: 10.1016/J.CYTO.2019.154794
关键词:
摘要: Early diagnosis and treatment of acute cellular rejection (ACR) may improve long-term outcome for lung transplant recipients (LTRs). Cytokines have become valuable diagnostic tools in many medical fields. The role bronchoalveolar lavage (BAL) cytokines is unknown value to diagnose ACR distinguish from infection. We hypothesized that distinct cytokine patterns obtained by surveillance bronchoscopies during the first year after transplantation are associated with microbiologic findings. retrospectively analyzed data 319 patients undergoing at University Hospital Zurich 1998 2016. compared levels IL-6, IL-8, IFN-γ TNF-α 747 BAL samples transbronchial biopsies (TBB) results bronchoscopies. aimed define reference values would allow distinction between four specific groups "ACR", "infection", "combined infection" "no pathologic process". No definitive pattern was identified. Given overlap groups, these not suitable markers or infection transplantation.
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