Urinary and sexual outcomes in long-term (5+ years) prostate cancer disease free survivors after radical prostatectomy

摘要: After long term disease free follow up (FUp) patients reconsider quality of life (QOL) outcomes. Aim this study is assess QoL in prostate cancer who are disease-free at least 5 years after radical prostatectomy (RP). 367 treated with RP for clinically localized pCa, without biochemical failure (PSA ≤ 0.2 ng/mL) the ≥ were recruited. Urinary (UF) and Sexual Function (SF), (UB) Bother (SB) assessed by using UCLA-PCI questionnaire. UF, UB, SF SB analyzed according to: treatment timing (age time RP, FUp duration, age FUp), tumor characteristics (preoperative PSA, TNM stage, pathological Gleason score), nerve sparing (NS) procedure, hormonal (HT). We calculated differences between 93 NS-RP HT (group A) 274 non-NS-RP or B). evaluated correlation function bother group A to follow-up duration. Time since had a negative effect on positive (both p < 0.001). Elderly men experienced worse UF (p = 0.02 0.001) better Higher stage PCa negatively affected SF, (all: 0.05). NS was associated 0.05); conversely, More than 8 B similar. Group subjects (NS-RP HT) demonstrated worsening but improved SB, suggesting dissociation over time. Older higher outcomes RP. The direct up, no suggests that other issues (i.e: vascular neurogenic disorders), subsequent determinant urinary incontinence. maintained 7 years, which appear have divergent trajectories.