An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes.
作者： Hai-Tsang Huang , Tyler C. Lacy , Barbara Błachut , Gerardo X. Ortiz , Qiu Wang
DOI: 10.1021/OL4003866
关键词:
摘要: A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes achieved via the aminocyclization reactive unsaturated N-iodoamines, which can be generated in situ from either N-chloramines or their amine precursors a one-pot protocol.
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