Gluten Intake and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in Children at Increased Risk of the Disease: The Diabetes Autoimmunity Study in the Young (DAISY)
作者： Nicolai A. Lund-Blix , Fran Dong , Karl Mårild , Jennifer Seifert , Anna E. Barón
DOI: 10.2337/DC18-2315
关键词:
摘要: OBJECTIVE To study the association of gluten intake with development islet autoimmunity and progression to type 1 diabetes. RESEARCH DESIGN AND METHODS The Diabetes Autoimmunity Study in Young (DAISY) follows children an increased risk Blood samples were collected at 9, 15, 24 months age, annually thereafter. Islet was defined by appearance least one autoantibody against insulin, IA2, GAD, or ZnT8 (zinc transporter 8) two consecutive blood samples. Using food frequency questionnaires, we estimated (in grams per day) from year age. Cox regression modeling early intake, joint cumulative during follow-up, used estimate hazard ratios adjusted for confounders (aHR). RESULTS By August 2017, 1,916 subjects included (median age end follow-up 13.5 years), had developed 178 participants, 56 these progressed We found no between 1–2 years (aHR 4 g/day increase 1.00, 95% CI 0.85–1.17 1.01, 0.99–1.02, respectively). similar null results Introduction CONCLUSIONS Our findings indicate strong rationale reduce amount high-risk prevent
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